Sentence examples for most conserved nucleotide from inspiring English sources

This algorithm identifies the most conserved nucleotide motifs within a set of homologous DNA sequences, under the premise that functional regulatory elements are more highly conserved under natural selection than non-functional DNA sequences [29].

It lies in [0, 1] and reaches 1 only if the predicted sequence corresponds to the most conserved nucleotide at each position.

In particular, our findings show that a nucleotide preferred at some position of a multiple alignment of binding sites for some transcription factor in the same genome is not necessarily the most conserved nucleotide in an alignment of orthologous sites from different species.

According to the TESS web page [ 17], the 163+37235 G position (TG GCA) is the most conserved nucleotide within the NFIX recognition sequence, suggesting the 163+37235A-allele may alter the affinity of this transcription factor to the cis-regulatory element.

In one late progeny population, the most conserved nucleotides of the splice site remained unchanged but the viral latency period was no longer compromised.

Interestingly, the three most conserved nucleotides in the G. lamblia polyadenylation signals are the central TRA nucleotides, which is similar to the situation in S. salmonicida.

For example, in the logo shown in Figure 1, uniform background frequencies are assumed, and the most conserved nucleotides have an entropy of 2 bits (derived from an observed frequency of 1.0 compared to the expected frequency of 0.25).

In the present study, the most avoided codon pairs in X. dendrorhous were consistent with the described patterns, i.e., CC UAAG, GA GUC C and AA CCG A, and the most preferred codon pairs were GC GCTC, GU UC CC, AC UC CU, UC UU CU and UC UU CC (the most conserved nucleotides in each pattern are in italics).

In the most conserved tRNAs the nucleotide substitutions are largely restricted to TΨC and DHU loops and extra arms, with changes on acceptor and anticodon stems reduced to 0-3 fully compensatory base changes (cbcs) (e.g., G-C vs. A-T in the anticodon stem of trnG) and/or hemi-cbc (e.g., G-T vs. A-T on the acceptor stem of trnM) [ 75].

While variants of the most conserved splice site nucleotides at the intron-exon boundary can be predicted to cause splice defects with high reliability, it remains difficult to predict whether variants deeper in the intron or those that potentially affect exonic splicing enhancers actually cause splice defects.

Rex1 exhibited two evolutionary lineages, even being the most conserved TE with few nucleotide substitutions.