Sentence examples for most conserved member from inspiring English sources

SIRT1 is the most conserved member of sirtuins, a family of NAD+-dependent protein deacetylases, and contributes to deacetylation of multiple mammalian transcription factors such as p53, FOXOs, and NF-κB in nucleus, making it a key metabolic regulator involved in a vast number of cellular processes associated with age-related diseases including AD (Guarente, 2011; Herskovits and Guarente, 2014).

It also shares with R. prowazekii a unique split gene, scaI, that is the most conserved member of the scas and is present in all analyzed Rickettsia spp. [57].

Caspase-2 represents the most conserved member of the caspase family, which exhibits features of both initiator and effector caspases.

Dnmt2 is the most conserved member of the DNA methyltransferase family, and Dnmt2 homologues can be found in nearly all species (Schaefer & Lyko, 2010).

These results suggested that OSCA4.1 is the most conserved member of the OSCA family, and that deletions in OsOSCA2.2 and ObOSCA4.1 occurred independently during rice evolution.

IGFBP5, the most conserved member of the IGFBP family in all vertebrates, has been shown to regulate cell growth, determine cell fate, and play a role in the metastatic process in cancer development.

Another pluripotency-silencing miRNA is let-7, one of the founding and the most conserved members of the miRNA family (Pasquinelli et al., 2000; Reinhart et al., 2000).

In addition to SirT1, SirT3 is a member of the class I sirtuins, the most conserved members of the Sir2 gene from S. Cerevisiae.

The chordate PACAP shares in general 92% of amino acid sequence similarity with VIP and these two peptides are the most conserved members.

Currently, eleven PRMT family members have been identified in the metazoans, with PRMT1 (Type I) and PRMT5 (Type II) being the most conserved members of the PRMT family across the eukaryotic spectrum reviewed in [ 4].

The most evolutionary conserved member, iASPP, is the inhibitory form and the only ASPP family member identified in Caenorhabditis elegans (Bergamaschi et al, 2003b).