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Our study revealed that Group H is the most conserved group of bZIP homologues; members of this group are present in all green plant lineages.
Later on, considering monogenic (Mendelian) and polygenic (complex) disease genes, Podder and Ghosh (2010) found that ND genes are the most conserved group, whereas polygenic disease genes are the least conserved among the three gene sets.
These groups include miRNAs that are present only in humans (G5); miRNAs that are conserved in primates (G4); conserved in mammals (G3); conserved in vertebrates (G2); or conserved in other more distant species (G1, which is the most conserved group).
Bootstrap analysis revealed three groups of ComI homologs, with ComIDSM13 forming the largest and most conserved group (Fig. 1a, c).
We analyzed the most conserved group, 705 syntenic orthologs.
This observation clearly depicts that the most conserved group of genes is indeed the most sensitive ones to variation.
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By splitting genes into ten groups based on average GERP score, we observe a depression in MAF around genes for the eight most conserved groups of genes (Additional file 1: Figure S8 and Table S1) and the depth of the depression in MAF correlates significantly with the average GERP score of genes in each bin (r = 0.98, p < 0.001, Figure 1B).
The most strongly conserved group of homologues in algae and angiosperms is Group H which includes light control factors HY5 and HYH.
Several lines of evidence indicate that CD99 shares some important properties with HSP70 – a member of heat-shock proteins, most conserved protein group in living organisms, abundantly expressed on the constitutive level or upon external influence.
In addition to recruiting D3 into the core, the D2 stem directs the folding of the adjacent j2/3 linker, which is among the most conserved elements in the group II intron active site.
Despite this large range of metal dependencies, several metal-binding sites have been discovered in the most conserved domains of the group II introns, including D5 and D6.
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