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"It just happens that Gauley is the one I love the most and have the most connection to," she says, noting that the documentary is not literally about only Gauley Mountain.
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Cathay Pacific claims the most connections to Chinese cities through its Hong Kong hub.
My concern is not over short-term bans but instead whether there should be a permanent block on most connections to the outside world in national parks and wilderness areas where people go to spend days or longer "getting away from civilization".
The gene KRAS was ranked 1st in the DEG list and had the most connections to the cancer-related pathways.
Transcription factors with the most connections to other genes included EPAS1 (also known as HIF-2α), KLF13, TAL1, TBX3, GATA2, and BCL11A (Additional file 4).
The genes with the most connections to neighbors in the network of 326 genes were Il1b (interleukin 1 beta; 144 connections), Fn1 (fibronectin 1; 100 connections) and Igf1 (insulin-like growth factor 1; 99 connections) (Additional file 4: Figure S2).
The growth factors IL1B, IGF1 and CXCL10, and the receptor CXCR4 have the most connections to other genes, so these are candidates in the regulation of follicle assembly to investigate in future studies.
When we evaluated the network created by the 39 genes identified only by cluster analysis, we again found that TNF-α and INF-γ have the most connections to other genes in the network.
When we conducted pathway analysis on the list of 93 probesets that showed highly significant differences between the two strains of mice, we created a network in which IFN-γ and TNF-α were the most central (i.e., had the most connections to other genes in the network).
The gene-pathway bipartite network of 50 DEGs connected to the 20 cancer-related KEGG pathways was shown in Figure 2. The gene MAPK1 was ranked 1st in the DEG list and had the most connections to the cancer-related pathways.
It can be seen from Figure 1 that the gene CCND1, which was ranked 1st in the 1010 DEGs, had the most connections to the cancer-related pathways, indicating it was an important feature for the prediction of the clinical endpoint of breast cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com