Sentence examples for most connected proteins from inspiring English sources

Thus, by identifying the most connected proteins (or hubs) in protein interaction networks (PINs), one may discover prospective drug targets that can be utilized to combat emergent and drug-resistant pathogens such as Methicillin-Resistant Staphylococcus aureus 252 (MRSA).

MMP-3, IL-8 and MGP were also the most connected proteins in the ProteinProphet network.

The results indicates that the use of biological information can improve the identification of the most connected proteins.

They concluded that "the most connected proteins in the cell are the most important for its function".

Among the most connected proteins (with more than 100 interactions in the network; Table  3) the first 2 proteins in the list were PRKAA1 and PRKAA2, subunits of AMP-regulated kinase (AMPK).

These networks can be used to identify relationships between proteins; they also provide a visual way of viewing those proteins that are frequently in rules through identification of the most connected proteins.

The most connected protein in module 4 is Hog1p (High Osmolarity Glycerol response), which has a connectivity degree of 54 (Fig.  3c).

The second-most connected protein of the replicase complex is nsp8 (figure 2A, 2B).

The correlation between the top-20 high-traffic proteins and the top-20 most-connected proteins was: 0.98 (Pearson correlation, P = < 1E-5) and 0.84 (P = <1E-6) for traffic and degree values respectively.

Several proteins in the mediator list are represented in the pathway (see Additional file 4: Figure S4) including GSK-3β, a tau kinase that was also included in the most connected mediator proteins list (Table  3) and in the autophagy-related proteins (Additional file 3: Table S3).

Jeong et al. showed that most highly connected proteins in protein-protein interaction networks are crucial to cell viability [ 24].