MPSS expression studies of different human cell lines and normal tissues have already shown that this technology represents the most comprehensive sequencing methodology available at present, in terms of gene coverage and quantitative assessment of gene expression [ 22, 39].
When more than one publication was identified from the same study, we designated the publication with the most comprehensive etiology results or methodology details, longest surveillance period, or the oldest reference, as the "main publication".
Ladouceur et al. provide one of the most comprehensive evaluations of rare variant methodology to date [ 31].
The updated Cochrane systematic review that is summarised in this paper represents the most comprehensive overview, using a rigorous methodology, of the existing body of evidence of the effectiveness of interventions aimed at improving appropriate polypharmacy in older patients.
However, it should also be noted that this is one of the most comprehensive comparisons of module detection methodologies employing modularity maximisation, to our knowledge.
One of the principal objectives of Colford 2002 USA was to assess the effectiveness of its blinding methodology; it therefore provides the most comprehensive analysis of these issues.
The methodology used focused on one of the most comprehensive patent database, Orbit.com, covering about 70,000,000 documents.
To extend characterisation of T2D GWAS loci, the most comprehensive fine-mapping experiment requires an exhaustive catalogue of variation across the region and necessitates powerful methodology to integrate statistical evidence of association with regulatory and functional annotation to reflect our prior beliefs about the likely mechanisms through which variants will impact on disease risk.
Many organizations and groups assess the fragility of states using different criteria, but often with similar methodologies and findings.6 The Fund for Peace provides one of the most comprehensive measurements of political stability through data on 12 primary social, political, and economic indicators for 177 countries.
Nevertheless, to our knowledge, this is the most comprehensive crosscountry data-set on CBO funding and expenditure collected at the community level using a consistent methodology.
