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The systematic review of 64 studies by Sidorchuk et al. [ 26] constitutes the most comprehensive data collection on SES and lung cancer incidence to date.

The publicly available lung focused Cell Proliferation Network described here represents the most comprehensive and fully referenced mechanistic representation of the signaling pathways that regulate normal lung cell proliferation in existence, and is compatible with analysis using systems biology data.

To the best of our knowledge, this lung-focused Cell Proliferation Network provides the most comprehensive connectivity map in existence of the molecular mechanisms regulating cell proliferation in the lung.

This lung-focused, fully referenced Cell Proliferation Network provides the most comprehensive publicly available connectivity map of the molecular mechanisms regulating proliferative processes in the lung.

In a related paper, we report the first large-scale application of this technology to discover and verify novel biomarkers for lung cancer in one of the most comprehensive proteomic biomarker studies published to date [40].

However, although "push-button" protocols facilitate its clinical application, lung MRI can be still challenging, being the most comprehensive but also most expensive and least robust of the three modalities.

Besides chest radiography, the most commonly employed first-line test for chest disorders, and computed tomography (CT), so far the most comprehensive and detailed modality for cross-sectional and three-dimensional (3D) imaging of the lung, MRI is becoming an alternative, third method for the assessment of pulmonary diseases.

One of the most comprehensive radon studies performed in the United States by Dr. R. William Field and colleagues found a 50% increased lung cancer risk even at the protracted exposures at the EPA's action level of 4 pCi/L.

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