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Besides, most compounds were moderately active against Plasmodium falciparum.
Most compounds were found to exhibit significant anti-cancer activity in vitro.
Regarding the cytotoxicity assessment of the series, most compounds were not cytotoxic.
Most compounds were highly potent and selective for human and rat H3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model.
Most compounds were identified as potent inhibitors for the enzyme with IC50 values ranging between 0.50 and 53.40 μM, with reference to standard d-saccharic acid 1,4-lactone (IC50 = 48.4 ± 1.25 μM).
Most compounds were found to be 1.5 4.5-fold 1.5 4.5-foldcy thighertramethylpotencye (than in stetramethylpyrazineiferaTMPn of normal vascular endothelinl cellstimulatingotheting against hyproliferation injury.
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As most compounds are composed of fewer than five elements, the input vector is very sparse.
This library is suitable for a pilot screen, as it covers all major drug target classes and most compounds are commercially available, satisfactory for the requirements of orthogonal screening34.
Most compounds are highly water soluble.
The MW of most compounds is between 220 and 540 Da.
Examination of the table reveals that most compounds are efficient gelators, except that TC12-Lu cannot gel any present solvent.
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