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In general, most compounds show good anticancer activity against all three tested cancer cell lines.
Most compounds show specificity towards TryR with only two displaying preferential inhibition of GR (ratio GR IC50/TryR IC50 <1) and two displaying poor selectivity (ratio GR IC50/TryR IC50>1 and <3).
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Most compounds showed moderate to excellent activity.
Most compounds showed potent HDAC6 inhibition activity.
Most compounds showed moderate to excellent potency.
Most compounds showed moderate-to-excellent antiproliferative activity.
Most compounds showed moderate to excellent antitumor activity.
Most compounds showed significant peripheral and/or central analgesic activity.
Most compounds showed weak to excellent antiproliferative activity.
Most compounds showed moderate to excellent inhibitory activities.
Most compounds showed high affinity and selectivity for S1P1 receptor.
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