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While we found most compounds did not have any effect on Notch cleavage in vitro, AD 28.
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Comparison of the calculated dietary exposures with the generally accepted health-based guidance values revealed that most compounds do not pose any risk.
While many potential candidates possess some anti-spermatogenic or anti-fertilizing activity, most compounds do not eliminate gonadal sources of testosterone [ 4].
In our dataset, more than half of the fingerprint properties have high-class bias rate, with a large majority of the dataset belonging to the positive class (most compounds match the property) or respectively the negative class (most compounds do not match the property).
Most of the compounds did nothing, but several compounds that blocked a cell surface protein called the epidermal growth factor receptor (EGFR) had impressive effects.
The results demonstrated that the treatment with most of the compounds did not affect HCV IRES driven translation (Fig. 4).
Moreover, most of the compounds did not affect HCV IRES driven translation indicating that the major antiviral mechanism is to directly inhibit virus genome replication.
Most of these compounds did not undergo further development, partially due to their unknown binding mode to allow for further optimization of their structures.
As expected, most of these compounds did not affect viability of control FAK-/-p53-/ cells, except for R9, R10 and R13 or PANC-1 cells with mutant p53, except for R9,R10 and R13 (Additional file 1: Figure S1).
Unfortunately, most of the synthesized compounds did not show an obvious activity against influenza B; the only exceptions were compounds 5d and 5f, which had IC50 values of 17.3 and 3.2 μM, respectively.
The HSP dataset was the most difficult for scoring, as active compounds did not contain remarkably populated HB contacts.
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