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This could signify that most complex variations mediate cellular functions that are important for strain fitness independent of the growth conditions.
Gavin et al. suggested that protein complexes in yeast have a modular architecture with each complex consisting of a core of proteins found in most complex variations (i.e. complex isoforms) and certain attachments depending on the particular cellular conditions [ 9].
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Daytime [He+] was the most complex component, showing negative variation with solar activity at low latitudes over Southern Hemisphere and positive correlation at middle latitudes over Northern Hemisphere.
It has now been widely accepted that standard GWAS explains at most a small fraction of the population variation of most complex traits (Frazer et al., 2009).
There is increasing evidence that genetic variation in most complex quantitative traits is the result of many mutations of small effect that individually explain only a small portion of the genetic variance [ 1– 5].
The genetic basis of population variation for most complex traits, like muscling, is thought to be the result of contributions from a large number of polymorphic genes each of small effect size.
A kid in his twenties walks into a lab, defines the variations in one of the most complex regions of the human genome, and shows how the variants might underlie the risk of schizophrenia.
He wants to make us appreciate that even the most unmelodic theme can generate an infinite number of complex variations.
A focus on this historic period offers the most complex possible scenario to observe a wide range of the variation in individual reactions towards the changing employment environment.
The results show that the most complex model, which allows for both branch-specific and family-specific rate variation, achieves the best fit, without overfitting.
RAxML implements only GTR as the most complex and general model of nucleotide substitution, suitable for datasets with genomewide variation (Stamatakis 2014).
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