Exact(2)
Asphaltenes constitute the most complex fraction of crude oil.
The distribution profile of sequenced sRNA showed that the most abundant and most complex fraction was the sRNA of 24 nt in length, followed by 22, 23 and 21 nt, in agreement with published reports of maize small- RNA libraries [ 54– 54].
Similar(58)
First, the method for scaling tumor segmentation to a common baseline value (usually log2 = 0) affects the status of alterations in a small fraction of the most complex tumors (Figure S9).
Consequently, current GWAS of most complex traits only have identified a small fraction of trait variance (5 to 10%), leaving much of the heritability of these traits unexplained [6].
It has now been widely accepted that standard GWAS explains at most a small fraction of the population variation of most complex traits (Frazer et al., 2009).
SNPs either individually or in combination typically explain only a small fraction of the genetic variance of most complex traits 5, 6.
Unfortunately, for most complex traits the discovered SNPs explain only a small fraction of the estimated heritability, a phenomena often referred to as the 'missing heritability' (Maher, 2008).
Although genome-wide association studies have identified numerous SNPs that associate with CAD [ 4- 7], as with most complex traits, the discovered variants explain only a small fraction of risk [ 8].
This fraction has been dubbed as missing heritability that for most complex diseases is larger than 50% [ 3].
However, for most complex diseases, the GWAS association signals are only able to explain a small fraction of the overall heritability that is predicted by classical heritability analysis (Visscher et al., 2008).
This contrasts sharply with even the most complex mixtures of biomolecules extracted from any living organism, from which molecularly pure fractions can be readily obtained.
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