Sentence examples for most commonly dysregulated from inspiring English sources

The PI3K/mTOR-pathway is the most commonly dysregulated pathway in epithelial cancers and represents an important target for cancer therapeutics.

Of these, EGFR is the most commonly dysregulated RTK in BTBC.

Among the most commonly dysregulated miRNAs in PDAC are miR-21, miR-155, miR-221, miR-216, and miR-217.

A report from The Cancer Genome Atlas project (TCGA) identified the most commonly dysregulated pathways in GBM (TCGA, 2008).

In this report, we have shown that EGFR, the most commonly dysregulated RTK in BTBC [ 41– 43], cannot effectively activate downstream signaling without SHP2 (Fig.  2a d).

First, once enough disease risk genes are identified, concentration of genes in particular pathways can be statistically assessed, to ascertain which systems are most commonly dysregulated in disease, and which can serve as targets for drug development.

(b) Venn diagram showing specific and commonly dysregulated miRNAs in duloxetine and placebo responders.

Overall, we identified 84 distinct signaling pathways commonly dysregulated in all four data sets (Supplementary Table S1 and Supplementary Figure F1).

An additional set of commonly dysregulated genes were identified without concomitant alteration in DNA copy number.

Gene Enrichment analysis and pathway analysis were performed to identify gene ontologies and functions that are commonly dysregulated in relation to COPD in published gene expression datasets.

Altogether 561 genes were commonly dysregulated in both lines showing at least 2-fold difference in expression level between tolerant and parental cell lines.