Sentence examples for most commonly deregulated from inspiring English sources

PI3K/Akt signalling is one of the most commonly deregulated signalling pathways in cancer, which explains the massive attention from many pharmaceutical companies over the ten past years on these signalling molecules.

Foj et al. recently revealed that among the most commonly deregulated miRNAs (miR-21-5p, miR-375-3p, miR-214-3piR-214-3p and let-7c-5p) in PCa patients [105, 109, 110], miR-21-5p, miR-375 and let-7c-5p are significantly upregulated in urinary EVs from PCa patients compared with healthy controls [111].

The p53 network is the most commonly deregulated gene circuitry in human cancer.

Specifically, we focus upon the mitochondrial pathway of apoptosis the most commonly deregulated form of cell death in cancer.

The primary goal of our study was to identify the most commonly deregulated genes in invasive breast carcinomas related to ERα status.

Ras/Raf/ERK pathway is among the most commonly deregulated pathways identified in tumors, as indicated by frequently observed activating mutations in Ras or B-Raf oncogenes [ 13].

Pathways commonly deregulated in HNSCC might be targeted by most expressed and also by differentially expressed miRNAs.

We next conducted an ontology analysis of the 1319 transcript clusters commonly deregulated in liver and kidney using the DAVID gene functional classification tool to reveal the most affected gene categories.

The most useful result of applying this modified t statistics beta binomial test is the identification of genes and gene families commonly deregulated across samples within each specific stage in the transition from normal to preinvasive and invasive stages of breast cancer development.

Therefore, we investigated at the molecular level if some genes were commonly deregulated in both mutants.

The percentages of commonly deregulated genes and the mean correlation coefficients increased with compound concentrations.