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To assess for the deletion of chromosome 13, we used D13S319 (regarded to be the most commonly deleted region in some studies [ 38]).
PTEN is the most commonly deleted tumor suppressor gene in primary prostate cancer (PCa) and its loss is associated with poor clinical outcomes and ERG gene rearrangement.
Among the CRC genes established by Sjöbolm et al [23], the most commonly deleted in our samples were EPHB6, EXOC4 (SEC8L1), GNAS, MLL3, and TBX22.
The most commonly deleted region was flanked by D10S215 and D10S541 and encompasses the PTEN locus.
This region was the most commonly deleted in both the favourable (64%) and unfavourable (83.3%) stages.
1p36.11-12 was the most commonly deleted region of 1p36 in both the current study and in the TCGA validation set.
Similar(47)
Collectively, our data provides direct evidence supporting the hypothesis that haploinsufficiency of multiple genes in the commonly deleted segment is the most likely relevant genetic consequence of deletions spanning chromosome 5q31.2.
Human HIG2 is located on 7q32.2, a commonly deleted region in several tumour types, most prominently leukaemias and lymphomas [ 57].
Detailed deletion mapping revealed two distinct commonly deleted regions.
Detailed deletion mapping identified two independent commonly deleted regions on this chromosome arm.
Moreover, PARD6G is a commonly deleted gene in cancer (Figure 6d).
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