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Anti-Jo-1 and anti-PL-7 were the most common specificities, accounting for 68% (15/22 patients) and 23% (5/22 patients) of anti-synthetases, respectively, whereas anti-PL-12 and anti-KS were rare (one patient each).
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In DM, no patient had anti-Jo-1 antibodies, while in PM it was the most common autoantibody specificity (0% vs 24%; P = 0.0087).
The most common binding specificity for the PX domain appears to be for PI(3 P; hence, several PX domain-containing proteins localize to PI(3 P-rich endosomal and vacuolar structures through this domain.
Almost all sera with anti-Ro60 (91%; 10/11 patients) displayed anti-Ro52 as well, confirming that among patients with AIM the most common anti-Ro specificity is anti-Ro52 [ 40].
The most common method of estimating specificity has been to perform nerve conduction tests on a group of "normal" persons who in almost all previous studies have been recruited among hospital employees or similar convenience samples.
Currently, high-throughput screening methods, such as microarrays, can be applied to detect miRNAs in prostate FFPE tissues; however, quantitative real-time reverse-transcription PCR (qRT-PCR) is still one of the most common high sensitivity and specificity methods used to detect low miRNA levels [ 37].
The most common way of defining the specificity of cognitive deficits in vascular dementia is based on comparison with AD patients.
Serum autoantibodies appear as a consequence of systemic B-cell activation that is targeted toward self-specificities, the most common targets being nuclear proteins.
In addition, we assessed the sensitivity and specificity of the most common of these clinical findings.
The validated DC/TMD with established sensitivity and specificity for the most common OFP/TMD conditions comprise strict clinical procedures and diagnostic criteria.
The lack of specificity of the most common PET tracers and the poor resolution of the PET cameras are seen as the major limitations of PET imaging [3, 5, 14].
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