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Age-related macular degeneration (AMD) and retinitis pigmentosa (RP), which eventually affect the photoreceptors, are the two most common retinal degenerative diseases.
The focus of this review is to summarize the genetic background of the most common retinal diseases, highlight current concepts of gene delivery technology, and relate those technologies to pre-clinical and clinical gene therapy studies.
AMD was the most common retinal disease, which was found in 371 subjects (37 %).
Macular oedema secondary to RVO (BRVO or CRVO) is the second most common retinal vascular disease after diabetic retinopathy.
Being a part of the entity, RVO is the second most common retinal vascular disease after diabetic retinopathy.
Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy and is an important cause of vision loss [ 1].
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Retinitis pigmentosa is the most common inherited retinal degeneration and a major cause of visual impairment among individuals aged 20 64 years.
CRVO is therefore considered the third most common vascular retinal disease that leads to blindness [ 10].
It is the most common hereditary retinal disease with a frequency of approximately 1 in 3000 4000 people, with an estimated total of 1.5 million people affected worldwide [ 1, 2].
AMD (28.3%) was the most common vitreo-retinal disorder.
AMD has been the most common vitreo-retinal disease found in previous studies [ 2, 3].
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