The most common responses?
Most organisms (and Escherichia coli among the faecal bacteria by far the most common) are responsive to cheap and available antibiotics.
Considering that uterine fibroids (i.e., leiomyomas, myomas) are one of the most common hormonally responsive tumors clinically affecting women of reproductive age, it is a first-line strategy to identify potential environmental risk factors for the management of this disease (Di et al. 2008; Gao et al. 2012).
In this large series, HNF4A mutations are the third most common cause of diazoxide responsive HH.
Homozygosity or compound heterozygosity for the c.833T>C transition (p.I278T) in the cystathionine beta-synthase (CBS) gene represents the most common cause of pyridoxine-responsive homocystinuria in Western Eurasians.
Mutations in GCH1 are the most common cause of DOPA-responsive dystonia (DYT5; OMIM#128230) (Clot et al., 2009), a rare movement disorder that presents typically in childhood with lower limb dystonia and subsequent generalization (Nygaard, 1993 b ).
Loss-of-function mutations in GCH1 result in severe reduction of dopamine synthesis in nigrostriatal cells and are the most common cause of DOPA-responsive dystonia, a rare disease that classically presents in childhood with generalized dystonia and a dramatic long-lasting response to levodopa.
The most common fusion links the TMPRSS2 androgen-responsive promoter and the transcription factor gene ERG (Tomlins et al, 2007).
Remarkably, it has been shown that one of the most common tumor-derived mutant forms of the AR, AR-T877A, is responsive to activation by BPA (Wetherill et al. 2002, 2005).
In human, hematological immune mediated diseases, non responsive to medical treatment, ITP and hemolytic anemia are the most common indications of splenectomy [ 12, 13].
