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The most common MS component was elevated F-glucose, followed by low HDL and elevated WC (Supplementary Table 1).
The most common MS model, experimental autoimmune encephalomyelitis (EAE), is an autoimmune driven CNS demyelinating disease [ 12] that also exhibits neuronal damage [ 13- 15].
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Antisera to 61 of 86 internationally recognized M types, representing the most common M types (13 ), were available; strains for which an M type could not be assigned were classified as M nontypeable.
In humans the most common CTX-M variants are blaCTX-M-14 and blaCTX-M-15 [ 3].
In contrast, the specimens from the Western Australian subspecies, H. m. duboulayi, share a single haplotype that differs from the most common H. m. merope and H. m. salazar haplotype at 25 sites.
While CTX-M-15 is the most common CTX-M type in the Middle East region and North Africa, other investigators have reported that CTX-M-15 was not more prevalent than CTX-M-1 among the fecal isolates [ 16, 35].
In summary, although blaCTX-M-14 was the most common blaCTX-M variant in China, the present study together with recent reports [ 6, 7] suggested that blaCTX-M-15 has emerged in China.
This indicates that H. m. duboulayi is considerably divergent from the other two subspecies, as is the congeneric H. penelope which differs from the most common H. m. merope and H. m. salazar haplotype at 34 35 sites.
In Spain, Portugal and England blaCTX-M-14 was the most common CTX-M genotype.
This is another example of overlapping patterns between observations in wild birds and in humans, as blaCTX-M-15 is also the most common CTX-M variant in humans in Sweden [ 3, 44].
These results further emphasize that this enzyme is now one of the most common CTX-M β- lactamases worldwide.
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