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The most common methodological approach to analyzing the innovativeness of firms has been the use of a knowledge production function (KPF) (Acs et al. 2002).
To identify the most common methodological short-comings, we explored the proportion of articles that met or failed to meet each item separately (Table 2).
A list of the most common methodological issues with these six studies is shown in Table 1.
The most common methodological limitation was the lack of a power calculation to justify whether the sample size used in the study was adequate.
The research design entailed a review of economic evaluations, submitted for reimbursement of pharmaceuticals, by two independent academic reviewers to identify the most common methodological problems.
Overall, 50 consecutive economic evaluations that had been submitted for reimbursement of pharmaceuticals in 2007-2008 were selected by the HTA Office to be scrutinized by the two independent academic reviewers for the most common methodological problems.
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Allocation concealment was the most common approach to assessing methodological quality, used in 96.9% of reviews.
This study aimed to report on a first experience with the newly developed risk of bias in systematic reviews (ROBIS) tool and compare it with A Measurement Tool to Assess Systematic Reviews (AMSTAR), that is, the most common used tool to assess methodological quality of systematic reviews while assessing validity, reliability, and applicability.
A number of systematic reviews (Cochrane: 86%; non-Cochrane: 49%) also assessed other methodological items, the most common being whether trialists had carried out an intention-to-treat analysis (n=29), evidence of baseline imbalance (n=27), funding source (n=26), small sample size (n=17), early stopping (n=12) and lack of reporting of a power calculation (n=11).
First, poor methodological design is one of the most common problems confronted by both complementary and alternative medicine.
Our search for methodological publications in which moderator analysis was considered was limited; most common databases (PubMed and Web of Science) do not currently allow one to filter for methodological papers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com