First, the AGCAGAC-GGTCTGC pair, found in the CeRep25B element, displayed four peaks in its distribution (at 16, 29, 33, and 34 bases), corresponding to the most common intervals between the two oligomers within this minisatellite.
A systematic literature review showed that the effective dose was 93.2 μg/kg, the frequency of administration was 2, and the most common administration interval was 2 h [3].
Across all indications, the majority of treatment intervals (51.6%) with incobotulinumtoxinA were 5 months or longer, with ≥6 to <9 months being the single most common treatment interval (23.3%), followed by ≥4 to <5 months (16.1%).
The most common dosing interval used for the aerosolised antibacterials currently available or in development is a cycle of 28 days on treatment followed by 28 days off treatment.
When we apply the progressive detection of common intervals, accepting at most two common interval breaks, we obtain 263088 sequences distributed in 6 progressive near-perfect subtraces (subsets of traces 1, 2, 3, 4, 7 and 11).
By plotting blasted E value of the small RNAs against total number of unique sequences (Figure 1), we found that the most common conservation intervals were <e−2 (123 sequences), between e−2 and e−3 (63 sequences) and followed by <e−8 (48 sequences).
The longitudinal data accrued in most natural history cohorts to date are limited by participant burden and cost, with bi-annual visits being the most common time-interval.
For example, the plots for the AGCAGAC and GGTCTGC motifs both clearly highlight two peaks (at 31 and 63 bases), corresponding to the most common repeated intervals within the CeRep25B minisatellite.
This was the most common test-retest interval in our data.
