Sentence examples for most common inactivating from inspiring English sources

In the present study we screened for the most common inactivating polymorphism in CYP2D6, the CYP2D6*4 allele, which is present at a frequency of approximately 21 29%.

The most common inactivating mutations were large deletions resulting in loss of >20% of protein length (249), deletions causing frameshifts (221), then frameshift-causing insertions (187), and stop codons (102).

The most common mechanism to inactivate p53 function in human tumors is missense mutations; several compounds have been developed to restore activity of mutant p53.

We conclude that these findings confirm in a large sample that methylation is a frequent event in NSCLC, can also occur in smoking-damaged nonmalignant lung tissues, and may be the most common mechanism to inactivate cancer-related genes in NSCLC.

Laboratory studies show, for example, that the rhinovirus, the most common cause of colds, is inactivated at temperatures above 109 degrees Fahrenheit.

In the United States, the most common influenza vaccine is the Trivalent Inactivated Influenza Vaccine (TIV).

NFκB1 and NFκB2 are two major forms of the NFκB family in human [ 18], and they can be inactivated by the most common protein of I κB family, NFkB inhibitor α (IκBα) [ 19].

WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth.

Single-cell embryos were injected with 35 pg of mRNA expressing either human BRAFWT, the kinase-activating and most common CFC mutation BRAFQ257R, or the kinase-inactivating BRAFG596V mutation.

DNA methylation, which inactivates tumor suppressor genes, is the most common and well-characterized epigenetic change in human cancer and may be a potential biomarker for cancer [ 6, 7].

Retinoblastoma (RB, OMIM 180200), the most common pediatric eye tumor in the retina is initiated by inactivating biallelic variants of RB1 gene [ 1].