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The most common Grades 1 and 2 toxicities included diarrhea, abdominal cramping, anemia and nausea.
The most common grades 3 or 4 toxicities included fatigue (30%), peripheral neuropathy (10%), vomiting (10%), diarrhea (10%), and neutropenia (10%).
The most common grades 3 4 nonhematologic toxicities were diarrhea (17.1%), anorexia/nausea/vomiting (11.4%), and mucositis (8.5%).
The most common grades 3 and 4 AEs were proteinuria (11%), neutropaenia (8%), hypertension (5%), diarrhoea (5%), anorexia (5%), abdominal pain (5%) and AST/ALT elevation (5%).
The most common grades 3 4 non-haematological toxicities were asthenia (16.7%), hypokalemia (12.5%), vomiting (8.3%), stomatitis (4.2%), and diarrhoea (4.2%).
The most common grades 3 and 4 adverse events were dyspnea (8%), hyponatremia (8%), pulmonary embolism (4%), and arthralgia (4%) [ 42].
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Most common grade 3 4 toxicities were neutropenia (62%), neutropenic fever (22%), and diarrhea (32%).
The most common grade ≥3 AEs were haematological (45%), fatigue (10%), and pneumonia (7%).
The most common grade 3 or higher toxicity was neutropenia (45.9%), and thrombocytopenia was observed in 13.5% of patients.
The most common grade 3/4 toxicities, occurring in = 10% of patients, included neutropenia (21%), pulmonary toxicity (12%), and hyperglycemia (10%).
The most common grade 3 and 4 nonhematologic adverse events were neutropenic fever (25%), nausea (18.8%), and mucositis (9.4%).
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