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An important factor in our study design was that a medium dose (50 100 U) of BTX-A was used, because this is within the most common dosing range in our clinical practice.
The most common dosing interval used for the aerosolised antibacterials currently available or in development is a cycle of 28 days on treatment followed by 28 days off treatment.
One of the most common dosing schedules is 1.4 mg/m over 2 5 min on days 1 and 8 of a 21-day cycle, either undiluted or diluted in 100 mL of 0.9 % normal saline [ 17].
Nonetheless, two US medication-use evaluation studies, utilizing retrospective chart analyses, have shown that an unindicated initial dose of 200 μg every two weeks (Q2W) was the most common dosing choice by physicians at hospital and community oncology centers in these two studies [ 7, 8].
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The most common dose and dosing frequency error was that an entire day's dose was used in patients at one time, probably because of staff nurses' workload.
The most common dose is 0.625 milligrams a day, though a 0.3 milligram dose was recently shown to prevent bone loss.
Docetaxel and gemcitabine combination chemotherapy has been reported to be active against non-small cell lung cancer (NSCLC) and myelosuppression is the most common dose-limiting toxicity.
In patients on fibrates, a daily dose of 600 mg was the most common dose, used in 44% of these patients.
Therefore, using the most common doses of coelenterazine-h and H-89 in an RLuc8-based assay for PKA will result in a significant reduction in RLuc8 signal that could be wrongfully attributed to a decrease in PKA activity.
The most common dose of imipenem was 1 g/8 hours daily.
Hand foot syndrome was the most common dose limiting toxicity.
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