Sentence examples for most common activating from inspiring English sources

Besides the G12V HRAS mutation used in the transformation experiment to derive the premalignant cell line MCF10AT from MCF10A, the only mutation we detected was PIK3CA H1047R, which is known to be the most common activating mutation in the PIK3CA gene in human cancer [15], [16].

Furthermore, the KRAS and the BRAF proto-oncogenes were analyzed for the most common activating mutations applying pyro-sequencing.

The two most common activating mutations seen in patients are exon 19 deletions and the exon 21 L858R.

The most common activating point mutations are located in codons 12 and 13 of exon 2 of the KRAS gene (in over 90% of PDACs) [ 6, 27, 28].

However, our study showed that the most common activating PIK3CA mutations reported in other cancers were not frequent in gastric cancer.

In systemic mastocytosis, the most common activating mutation in C-KIT D816V, occurs in the catalytic region of the enzyme, and also prevents binding of imatinib.

The most common activated form of NF-κB in inflammatory cells consists of a p65 subunit and a p50 or p52 subunit [ 1- 3].

The most common EGFR activating mutations are in-frame deletions in exon 19 or point mutations in codon 858 in exon 21 [ 10].

Although monogenic neonatal diabetes may be caused by mutations in >20 different genes, the most common are activating heterozygous mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive K+ channel (KATP channel), which is highly expressed in pancreatic β-cells and brain (1).

The most common cellular signals activating the SOS response are regions of single-stranded DNA (ssDNA), arising from stalled replication forks or double-strand breaks, which are processed by DNA helicase to separate the two DNA strands.

These agonists bind to a subfamily of nuclear hormone receptors, the peroxisome proliferator-activated receptors (PPARs, including α, β/δ and γ isoforms, of which the γ isoform is the most common target), and activate transcription factors that modulate gene expression, ultimately leading to increased insulin sensitivity in peripheral tissues through poorly defined pathways [2], [3].