Sentence examples for most closely mimicked from inspiring English sources

In addition, we observed that the in vitro model which most closely mimicked in vivo mRNA phenotype varied with both the gene and the patient.

While the xenograft retained the primary tumor mutations, it most closely mimicked the mutation spectrum of the metastasis; that is, the PDX was genetically closer to the metastatic lesion than the primary tumor [ 53].

From these four robust lines that most closely mimicked wild type growth, a single line that was homozygous for the transgene was selected as a representative line for further study (Fig. 2F; line 1039).

In this way, they most closely mimicked the natural tendency of WS to skew a bit to the right when grown vertically in unit gravity, as opposed to on inclined plates, and this characteristic can be seen visually and in the quantification of the patterns shown in Figure 5.

Our primary interest in undertaking this gene expression profiling experiment was to ascertain whether gene expression patterns during in planta invasive growth were similar to in vitro stress conditions, and which condition most closely mimicked that of in planta invasive growth.

Here, we tested the hypothesis that gene expression patterns during in planta invasive growth are similar to in vitro stress conditions, such as nutrient limitation, temperature up shift and oxidative stress, and determined which condition most closely mimicked that of in planta invasive growth.

The optimal regimen is one that most closely mimics the normal pattern of insulin secretion, which is a constant low level of insulin secretion plus a pulse of secretion after each meal.

The virus is an H5N1 avian influenza strain that has been genetically altered and is now easily transmissible between ferrets, the animals that most closely mimic the human response to flu.

To test whether a similar difference would appear after id inoculation, which most closely mimics the natural transmission mode of bubonic plague, serial dilutions of Y. pestis CO92 and Y. pseudotuberculosis IP32953 were injected id into the ear of outbred mice and LD50s were calculated from the mortality rates after a 3 week follow-up.

CGL1 AGPAT2−/− mice most closely mimic the human condition with nearly absent adipose tissue, diabetes, high circulating insulin and triglycerides, and low circulating leptin.

Nevertheless, the present data indicate that it is necessary to select, for a given gene and a given tumour, the in vitro model most closely mimicking in vivo expression of this gene.