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The use of soluble CD4 has been found to be impractical as most clinical isolates are resistant to neutralization at feasible concentrations.
MIC are very low (≤ 0.125 μg/ml) for most clinical isolates of the species Candida albicans, Candida glabrata, Candida tropicalis and Candida krusei while Candida parapsilosis and Candida guilliermondii isolates are susceptible to anidulafungin concentrations ≤ 2 μg/ml.
In particular, natural transformation is increased by DNA damage in H. pylori, and a connection exists between the DNA damage response and DNA uptake in H. pylori, suggesting natural competence contributes to persistence of H. pylori in its human host and explains the retention of competence in most clinical isolates.
Most clinical isolates of S. aureus express either capsule type 5 (CP5) or 8 (CP8).
Most clinical isolates carry tst1, although this gene is absent in the genome sequence of Sanger MRSA252.
Environmental strains and most clinical isolates of P. aeruginosa involved in acute infections are flagellated and motile [1] [3].
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Most clinical encapsulated isolates do not show competence unless synthetic CSP is added (11 ).
Although most clinical MRSA isolates are susceptible to vancomycin, several studies have demonstrated that higher vancomycin minimum inhibitory concentration (MIC) levels (≥ 1.5 mg/L) of the causative MRSA isolates predict higher vancomycin treatment failure rates, despite of being susceptible to vancomycin [ 5, 6, 8, 9].
A multiplex real-time polymerase chain reaction procedure was developed to identify the most prevalent clinical isolates of Salmonella enterica subsp. enterica.
As could be expected, most MDR clinical isolates exhibited serotypes O11 and O12 (Figure 1, Figure 2, Figure 3, Figure 4, and Table 3).
Food-stuffs are mainly contaminated by serogroup 1/2 isolates, whereas most human clinical isolates belong to serotype 4b [ 21, 22], and among these, a small subgroup with unique gene clusters represent the two major epidemic-associated clonal groups [ 23, 24].
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