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However, whilst this arrest is independent of most checkpoint components it does require Mad3p [31].
Subcellular localization studies have placed most checkpoint proteins at the kinetochores and some of them (Mad1, Mad2, Bub1, Bub3 and BubR1) are present only at unattached rather than at fully microtubule-attached kinetochores [17], [18], [19], [20].
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Today most checkpoints are gone, though nerves remain jangled.
While the Rapiscan X-ray machines are now gone, similar body-scanners that use less controversial millimeter-wave technology remain in place at most checkpoints.
In the Gaza Strip, Israel removed most checkpoints it had placed along the main north-south road, permitting Palestinians to travel more freely than they had in more than two years within Gaza, which is fenced off along its 25-mile length.
The country is situated at the front of the Strait of Hormuz, the world's most important checkpoint, which connects the Arabian Sea and the Persian Gulf.
The whole 'review things in an amusing manner on the internet' thing has taken a macabre twist, with gulags in North Korea being rated on Google Maps and given verdicts like "Most exquisite checkpoint, made possible by Honourable Soldiers of Glorious Leader'.
Research on finding most suitable checkpoint intervals for different workloads, yet to happen.
Program/job resumes its execution from the most recent checkpoint instead of from the beginning of the program/job upon occurrence of failure.
FRAP studies of vertebrate BubR1, which is the Mad3 homologue, have shown that it is one of the most dynamic checkpoint components [8].
Although we believe Bcl-2 family proteins constitute a most important checkpoint upon mitochondria, it should be noted that various bistable switches downstream or independent of mitochondria have also been elucidated [33] [35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com