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NLRP3 is the most characterized of all the NLR inflammasome-forming proteins due to its abundant expression in macrophages and activation in response to the largest number of identified stimuli.
ADAM10 and ADAM17 are probably the most characterized of all the ADAM proteases.
Arguably, this is the most characterized of all PK/PD relationships of ECG interval changes due to the regulatory focus on the link between hERG, QT, and TdP.
This residue is located in a subunit called biotin carboxyl carrier protein (BCCP), and biotin is attached in an ATP-dependent reaction by a highly conserved family of biotin-protein ligases, the most characterized of which is the BirA enzyme from E. coli [ 1- 4].
Indeed, endothelial cells are able to synthesize and secrete a broad spectrum of anti-atherosclerotic substances, the most characterized of which is nitric oxide (NO), a gas that is generated from the metabolism of l-arginine by endothelial NO synthase (eNOS), constitutively expressed in endothelial cells (1).
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The most characterized member of the family is substance P (SP).
However, 13 (29%) were sampled during global outbreak week 05, representing the first identified (and most characterized cluster) of human influenza A/H1N1(2009) (H1N1pdm) infections in Nova Scotia (NS), Canada.
The most characterized element of the extrinsic pathway is caspase-8, which is lost in ∼70% of NBLs.
The most characterized class of small regulatory RNAs is miRNAs, which are 19 23 nucleotides (nt) single strand RNAs and highly phylogenetically conserved across almost all species.
The early conformation specific antibody MC1, and antibodies recognizing phospho-tau epitopes Ser202/Thr205 (and) and Ser396/Ser404 (PHF1) are among the most characterized identifiers of neurofibrillary pathology.
The multidrug resistance-1 (MDR1 or ABCB1) is the most characterized member of the ABC superfamily, also sometimes referred to as P-gp (P-glycoprotein).
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