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MtDNA haplogroup D, one of the most characteristic mtDNA lineages found in Northeast Asian populations, has been reported to be associated with various diseases.
Haplogroups D4 is one of the most characteristic mtDNA lineages found in Northeast Asian populations [25].
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Due to this characteristic, mtDNA has a higher susceptibility to the effect of recent demographic factors.
In parallel, we observed characteristic mtDNA duplications in the absence of MGME1.
The characteristic mtDNA mutation type in post-mitotic tissues (such as muscle and neurons) is the large-scale deletion [26].
Most characteristics were similar.
Owing to these characteristics, mtDNA is particularly susceptible to damage by mutagens and ROS (5, 6).
These genes are encoded in the same direction, a characteristic shared by most nematode mtDNAs.
Estimates based on these studies place the most recent mtDNA ancestor of all Neanderthals to approximately 250,000 years ago.
The most common mtDNA deletion is a 5-kb deletion (m.8470-m.13447), which is present in approximately one third of patients.
The mtDNA sequence data confirmed such an affinity (Figure S2), because the Hy haplotype was identical to the most common mtDNA haplotype in fish from Guaratiba, Brazil.
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