Drug discovery is one of the most challenging applied sciences due to the complexity of disease biology and the requirement to simultaneously optimize compound potency, selectivity, pharmacokinetics, physical properties, and safety in order to deliver an effective therapeutic agent.
In the nine countries that agreed to participate in that third test, students taking the most challenging math and science courses in their senior year were found to have performed progressively worse as they moved from elementary to middle to high school.
In the nine countries that agreed to participate in that third test, called the TIMSS Advanced, students taking the most challenging math and science courses in their senior year were found to have performed progressively worse as they moved from elementary to middle to high school.
Such discoveries cannot but change our ideas about ourselves and our world and drive us to the big question: "Are we alone?" We are in the midst of one of the most interesting and challenging science research programs that humans have ever pursued.
As it turns out, this is one of the most challenging tasks in computer science.
This is one of the most challenging problems in climate science, and one that my colleagues and I are working hard on.
The theory caused a furore when it was published and is still considered one of the most challenging ideas of modern science.
"Web search is the most challenging field in computer science," says Flake.
While much has been accomplished to date, we conclude that more work remains before comprehensive, efficient, and robust solution methods exist to solve the most challenging applications in subsurface science.
Ever since the development of the first computers, this lofty goal has been one of the most challenging problems in computer science.
