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"most challenging issues" is a correct and commonly used phrase in written English.
It refers to the most difficult or complicated problems or topics that need to be addressed. Example: The global leaders gathered to discuss the most challenging issues facing our planet, such as climate change and economic inequality.
Exact(60)
"This is one of the most challenging issues in the negotiations," Froman said about biologics.
"The high mobility of our children is one of our most challenging issues," she says.
This human-machine handover point is one of the most challenging issues for the industry.
Such disparity in test performance, which has also been seen from analysis of SAT scores, has become one of the most challenging issues in American education.
In a similar study conducted in 1992, 18percentt of participants cited public education as one of the city's three most challenging issues.
The recent allegations against Iran show the critical role that intelligence can play in helping policymakers gather information and make decisions on the most challenging issues.
One of the most challenging issues for Asian footballers claims Siddiqi is their cultural backgrounds and the lack of role models to inspire them.
One of the most challenging issues limiting current CDI cell performance is poor cycling stability.
The modelling and analysis of human behaviors is still one of the most challenging issues.
1 55pm: "We're going to address some of the most challenging issues facing consumers".
Planet bearing fault detection is one of the most challenging issues in planetary gearbox condition monitoring.
More suggestions(15)
most provocative issues
most formidable issues
most complicated issues
most sensitive issues
most critical issues
most contentious issues
most other issues
most fundamental issues
most challenging problems
most serious issues
most challenging cancers
most public issues
most regulatory issues
most challenging fallacies
most active issues
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com