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In most centres a multidetector CT (MDCT) is available with the possibility of performing isotropic multiplanar reconstruction in high quality.
At most centres, a margin of 1 mm is considered the threshold, yet others have chosen other thresholds [39, 40, 41].
In most centres, a combination of coronal, sagittal, axial fat-suppressed intermediate weighted sequences and a sagittal T1-weighted sequence is used for routine imaging of the knee.
Remediation methods vary across the schools and include, at most centres, a meeting with the professionalism director or their representative.
Overall, the technical aspects of the procedure for localising SN are quite uniform throughout the Veneto region and are consistent with the protocol used by GIVOM for its ongoing clinical trial on SNB [ 17]: in most centres, a subdermal injection of 30 50 MBq of 99mTc-albumin nanocolloids followed by lymphoscintigraphy is performed the day before surgery.
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Although PET is a valuable tool, it is expensive and, in most centres, remains a limited resource.
One would expect that the additional costs of integrated PET-CT not to be too dissimilar to FDG PET alone as most centres perform a low-dose unenhanced CT, which avoids the additional costs associated with intravenous contrast.
Since this was common, most centres adopted a 28-day interval for each cycle.
Most centres use a fixed dose of 7.4 GBq (200 mCi), but some use (much) higher activity doses.
Based on definitions supplied, most centres employed a cut off of ≥10% of tumour cells stained positive to define receptor positivity.
Most centres have a natural product 'aspect' to their compound collections, and these natural products might often be used when small-molecule probes are not easily identified; some centres specialize in this offering.
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