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Legitimisation is one of the most central selection mechanisms in any Triple Helix setting.
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The relation between selection and node centrality is less studied at the intra-species level, that is, among populations; however, in a recent study, Luisi el al [ 34] analyzed the patterns of human population differentiation of genes involved in the insulin/TOR signal transduction pathway and found that positive selection preferentially targets the most central elements in the pathway.
Taken together, these results indicate that the most central genes in the A. thaliana network are subject to stronger levels of purifying selection than those acting at the network periphery.
On the other hand, when we analyzed genes of special interest either because they show signatures of positive selection in the promoter and coding region or because they are the most central of Prom+ and Cod+ genes, we observed that most of these genes belong to enriched categories (Cell proliferation and differentiation, Development, Cell cycle, Signal transduction and mRNA transcription).
Remarkably, genes acting at the most central positions of the network (measured as degree, betweenness, or closeness) are subject to stronger levels of purifying selection than those acting at the network periphery.
Most Central Office staff were stunned.
The most central node is the root.
The most central of them is the Delphi method.
And the most central question of all: why?
The most central genes in this organization were conserved.
Actors L (head of the center) and B were most central.
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