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Doing so rewards you with a few laughs but no real insights, especially on the most central question: What turned Mike Tyson, who was until relatively recently a volatile man with a knack for making bad decisions, into the guy we're seeing now, a fellow who appears to be at peace with and able to laugh at himself?
And the most central question of all: why?
"Watergate has raised so many questions," Colson notes, but we are only confronted with one: "Can humanism ever be the answer for our society?" This, seriously, is the most central question that occurs to Colson in the context of Watergate, with the Nixon Administration somehow representing humanism.
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Despite decades of research on species-jumping pathogens, the most central questions in the field remain major stumbling blocks for societies that seek to mitigate their impacts.
As the author of 12 books, Maynard Smith introduced both scientific and lay audiences to some of evolution's most central questions.
It means integrating values into the most central questions of political life, including budgets and spending.
One of the least understood and most central questions confronting biologists is how initially simple clusters or sheet-like cell collectives can assemble into highly complex three-dimensional functional tissues and organs.
It is one of the most central philosophical questions underlying politics today.
Most striking, perhaps the central question behind the First Crusade has never really been asked: What happened at the end of the 11th century that made more than 60,000 men head east?
There were several debates among the science representatives of the three parties, but they struggled to differentiate their parties on most issues, including the central question of future research funding.
In epidemiological studies on cancer risk after CT scans, in which information on PF is most often inaccessible, a central question is to determine to which extent risk estimates without considering PFs at all might be biased or not.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com