Sentence examples for most cellular folates from inspiring English sources

Most cellular folates carry a short poly-gamma-glutamate tail.

In India, most cellular service is prepaid.

A deficiency in cellular folates results in aberrant DNA methylation, point mutations, chromosome breakage, defective chromosome recombination and aneuploidy.

In their reduced form cellular folates function conjugated to a polyglutamate chain.

A diagram illustrating folate metabolism is shown in figure 1. Deficiencies in cellular folates result in aberrant DNA methylation, point mutations, chromosome breakage, defective chromosome recombination and aneuploidy [ 3].

Among other functions, ALDH1L1 has been known to deplete cellular 10-formyltetrahydrofolate pool resulting in a loss of de novo purine biosynthesis [ 23], maintain cellular folate concentrations by regulating the availability of THF [ 22], but most importantly, it has been shown to compete with the enzyme serine hydroxymethyl transferase (SHMT) for the polyglutamyltetrahydrofolates [ 25].

In addition to its role in cellular folate transport, FOLR1 is internalized, processed and transported to the nucleus where it regulates components of the FGF and NOTCH pathways30.

Furthermore, overexpression of MRPs and BCRP has been shown to result in decreased cellular folate pools, whereas loss of ABC transporter expression brought about a significant expansion in the intracellular reduced folate pool.

By inference, higher cellular folate might increase DNMT expression, and facilitate DAPK methylation.

At low, clinically relevant concentrations, metformin apparently induces the cellular folate cofactors to become metabolically trapped as 5-formimino-THF.

FA, the form of folate that manufacturers use for fortification, is a synthetic form of the vitamin that requires reduction to tetrahydrofolate (THF) before incorporation into the active cellular folate pool.