Exact(2)
Most cellular effects are triggered via long-lasting activation of second messengers ERK1/2.
Indeed most cellular effects of Mena and VASP, such as endothelial barrier function, fibroblast migration, and axon guidance, are associated with the regulation of β-actin actin dynamics [ 10, 11, 36].
Similar(58)
DSBs are considered to be the most deleterious cellular effects of x-rays, because they can result in loss or rearrangement of genetic information, leading to cell death or carcinogenesis [ 14].
There are several evidences that VEGFR-1, existing either as a membrane bound form or as a soluble form [ 33], may act as a VEGF trap due to its poor kinase activity and high-affinity to VEGF, moderating the amount of free VEGF available to activate VEGFR-2 [ 34], the key receptor mediating most of cellular effects of VEGF in the endothelium [ 1, 2].
In the primate dlPFC, D1 receptors are the most abundant DA receptor subtype, and mediate most of the cellular effects of DA in this subtype, and mediate most of the cellular effects of DA in this region [ 31].
Double-stranded breaks of nuclear DNA are considered to be the most important cellular effect of radiation leading to irreversible loss of the reproductive integrity of the cell and eventual cell death [4].
Most studies about cellular effects of ionizing radiation, including hadrons, were performed under growth conditions dramatically different from human homeostasis.
Most of the cellular effects of IGF-I and IGF-II are mediated by the IGF-I receptor (IGF1R).
Most cellular studies indicate an absence of effects on DNA, and generally biological data, including results from animal studies, do not demonstrate an increased risk of cancer from exposure to RF fields (Vijayalaxmi and Obe 2004).
In a recent proteomic study, this group identified a subset of 10 proteins containing thiol-insensitive SNO, which they hypothesize to be the most likely mediators of the persistent cellular effects of NO (58).
Modulation of protein phosphorylation through the antagonistic effects of protein kinases and protein phosphatases is a major regulatory mechanism of most cellular processes.
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