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However, since the RD genes were expressed within just a handful of expression domains and most cells expressing TGFβ and Hh appear resistant to transformation into retinal tissue, the mechanism that may permit and restrict ectopic formation remains unclear.

As these proteins are upregulated in most cells expressing the four reprogramming factors, and cMyc reportedly blocks p21 expression (Gartel et al, 2001; Seoane et al, 2002), it is unclear how ectopic expression of these four factors overcomes the cellular responses to oncogenes/transgenes overexpression and why only a very small population of cells becomes fully reprogrammed.

In colon cancer, several immunohistochemical studies reported that cancer cells had TP expression [ 39, 40], while other studies reported that most cells expressing TP were stromal cells, especially macrophages and lymphocytes [ 41, 42].

In the HEK 293T cells, most cells expressing βB11 142 and βB11 173 did not contain protein aggregates, while about 45% cells expressing βB11 229 with a GFP tag at the N-terminus contained p62-negative aggregates (Figs. 1F and S6).

The Oct4 staining demonstrated that most cells expressing the signaling molecules were undifferentiated mES cells.

In CEPH family 1345, paternal grandmother 7346 and granddaughter 7350, who inherited one of her paternal grandmothers alleles, show most cells expressing DXZ4 from the Xa.

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Similar(42)

Expression of pluripotency markers was highest and most consistent at the edge of the colony, where most cells expressed between 3 5 of the pluripotency markers shown (Figure 2b c).

Although most cells express adenosine transporters, there are few doubts that a main source of extracellular adenosine is hydrolysis of extracellular ATP by cell surface ecto-ATPases [8], [9].

In contrast, in OP explants cultured in the presence of DAPT (50 µM), the generation of Hes5+ and Ngn1+ cells was blocked and most cells expressed HuC/D (Fig. 4G), characteristic of post-mitotic neurons.

In Ker-CT-Ras epithelium there was little or no co-localization staining, suggesting that most cells expressed either keratin-14 or involucrin but not both (Fig. 6, left center).

Most cells express a variety of Bcl-2 family proteins and their balance dictates cell fate [ 18].

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