Sentence examples for most causal mutations from inspiring English sources

Previous work that applied this approach to viable mutants found that most causal mutations mapped to within 1 Mb of the highest peak in plots of pure parental allele frequency (Doitsidou et al. 2010, Minevich et al. 2012).

For the range of biological parameters observed among mutants isolated in Gruber et al. (2012) (shaded areas in Figure 1, B−M), we found that 20 generations or less of mitotic growth provided sufficient power to detect most causal mutations.

The most likely causal mutation was identified within exon 27 resulting in premature stop codon in the mRNA sequence.

We conclude that the 80-kb duplication, as the only remaining variant within the shortened Friesian haplotype, represents the most likely causal mutation for the polled phenotype of Friesian origin.

Combining the exhaustive sequencing data and high-density SNP genotyping results from previous studies [ 2, 4] and those reported here, we provide evidence that supports the P80kbID mutation as the only remaining and most likely causal mutation for the polled phenotype of Friesian origin.

Knowledge from Mendelian disorders indicates that most of the causal mutations in monogenic diseases are found in the coding regions of the genome [27].

We suspect that most of the putative causal mutations are loss of function mutations.

Genotypes should be dense enough to ensure that markers are in linkage disequilibrium with most of the potential causal mutations.

Nevertheless, the approach we have used should be able to identify the causal mutations in most TS-EL mutants processed.

More specifically, the regions most tightly linked to the causal mutations often have the highest frequency of pure parental alleles.

This suggests that most or even all of the causal mutations in Qrr1 act in cis.