Dicer is downregulated in most carcinomas, including HCC.
Although MUC-1 is expressed at very low levels in normal tissues; it is overexpressed by most carcinomas, including breast cancers [ 13].
There is now increasing evidence that stromal cells play a pivotal role in promoting the growth of most carcinomas, including breast cancer [ 1- 4].
This molecule is an attractive target for enzyme prodrug therapy, since it is highly expressed on the cell surface of most carcinomas, including colon tumours.
Studies investigating the role of cancer associated antigens in the diagnosis of malignancy, and in cancer progression have focused on the MUC1 antigen, which is expressed in an aberrantly glycosylated form in most carcinomas including breast cancer [ 1- 4].
The M30 antibody detects a caspase-degraded product, CK18-Asp396, of the important cytoskeletal protein cytokeratin 18 (CK18) of epithelial cells, which is expressed by most carcinomas, including those of breast, prostate, lung and colon [ 3].
The age-specific incidence data from most human carcinomas, including those of the colon, lung, prostate, and breast were consistent with the parallel route hypothesis.
Most other carcinomas, including adenocarcinomas, irrespective of their morphology, are essentially negative for K20.
There is increasing evidence to suggest most high-grade serous carcinomas, including those with bulky unilateral or bilateral ovarian disease, do in fact arise from the tubal fimbriae or secondary mullerian epithelial inclusions in the ovaries [9], [10], [11], [39], [40], [41].
Elevated levels are also found in most epithelial-derived human carcinomas, including breast, ovary, prostate, colon cancers, and high levels are correlated with poor prognosis [ 24].
Among the oncogenic miRs miR-21 is one of the most commonly overexpressed miRs in carcinomas, including prostate, breast, pancreas, colon, head and neck.
