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Subsequent studies have focused on Dido3, the largest and most broadly expressed isoform.
The death inducer obliterator (Dido) locus encodes three protein isoforms, of which Dido3 is the largest and most broadly expressed.
The Obp gene family was the most broadly expressed, followed by the Snmps, while the Or gene family had the most antennal-specific expression.
K+-dependent Na+/Ca2+-exchanger isoform 4 (NCXK4) is one of the most broadly expressed members of the NCKX (K+-dependent Na+/Ca2+-exchanger) family.
As expected,, genes associated with Cluster I CGIs are the most broadly expressed (tissue specificity is the lowest) compared with those associated with Cluster II and III CGIs (Fig. 5A).
In accord to the idea that gene expression plays a significant role in determining gene lengths, we observe that honeybee gene length decreases as the number of tissues where it is expressed increases (fig. 3 A ); the most broadly expressed genes are the shortest.
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Our results showed that Dicer inactivation resulted in a substantial loss of mature miRNAs as illustrated by the example of miR-124, the most abundant and broadly expressed miRNA in the nervous system [14] (Figure 2).
Most highly represented (broadly expressed) genes in Arabidopsis have best match orthologs in early divergent lineages.
We found such skewed distributions not only in the human data considered here (Fig. 3A), but also in several other datasets, e.g. most mouse genes are broadly expressed over different organs, most Arabidopsis genes are broadly expressed over different light conditions, and most zebrafish genes are broadly expressed over different developmental stages (Supplementary Fig. S4).
During larval stages, most Hox genes are broadly expressed in the ectoderm and developing VNC, largely share a common posterior boundary at the posterior growth zone, and have gene-specific anterior expression boundaries.
Interestingly, most genes encoding costamere as well as some Z-disk proteins appeared to be broadly expressed across most tissues and showed little change in expression during muscle differentiation, in line with the broader cellular role described for some of these proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com