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One included most breast samples, a second included the renal and bladder samples, and athird included most colorectal samples.
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FOXO3a cytoplasmic staining (p<0.0001, Chi-Square test) was also significantly associated with P-Akt staining, which is supportive that the activated P-Akt can negatively regulate FOXO3a and relocate it from the nuclear to cytoplasm in most breast cancer samples.
In the present study, we validated that Eag1 and HIF-1α were coexpressed in most breast cancer samples (91.1%).
Consequently, most breast cancer samples in cohort 2 were positive for ER and PR with a lower nuclear grade and fewer HER2 positive cases.
Exon 3 deleted PRΔ3 mRNA was seen at low levels in most breast tumour samples examined and in T47D cells [ 47, 49].
In most breast cancer samples, the relative luciferase activity of each of the promoters was significantly lower (p < 0.05) than the CMV promoter.
Normalization of spectra with the lipid residual signals removed will correct for differences in sample size and tumor cell content, as it can be assumed that most of the lipid signals from breast samples do not originate from cancer cells.
A positive correlation of differential expression between normal and malignant breast samples was observed for most SAS pairs.
Most breast cancers arise from epithelial cells; these cells sampled via milk could potentially be used to identify cancer biomarkers [ 27].
Most breast cancer gene expression studies to date have examined limited sample numbers and tend not to have sufficient power to allow analysis within standard clinicopathologically defined subsets.
To our knowledge, this is the most comprehensive description of AS at the BRCA1 locus reported so far in human breast samples.
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