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However, 25-hydroxyvitamin D requires conversion to its active metabolite, calcitriol, for most biological effects.
Most biological effects of LPS depend on its interaction with the TLR4 co-receptor MD-2, an event that triggers a cascade of signals leading to the NF-κB-dependent activation of immune response genes.
However, a common feature of most biological effects is the inhibition of eicosanoid production from n-6 fatty acid precursors.
Most biological effects of nitric oxide (NO) in the brain are mediated by guanylyl cyclase-coupled NO receptors, whose activation results in increased intracellular cGMP levels.
Most biological effects of ANP and BNP are mediated by a guanylate cyclase coupled cell surface receptor, the A-receptor (NPR-A) [ 44].
It is known that receptor for AGEs (RAGE) is a multiligand receptor expressed on many cells and mediates the most biological effects of AGEs [ 24].
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Perhaps one of the most important biological effects of TGF- β is its ability to inhibit proliferation of many cell types, including most epithelial cells (Moses et al, 1990).
In this article we intended to review the most important biological effects of thiazole-based compounds and highlight their roles in new leads identification and drug discovery.
The book begins with an overview of the basic science behind PRP, describing the role of platelets and growth factors followed by the most important biological effects expected from the use of PRPs.
One of the most important biological effects of TGF- β is its ability to inhibit proliferation of many cell types.
One of the most important biological effects of Rap1 signaling is the acute regulation of cell adhesion, in part, mediated by the activation of integrins.
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