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This study gives a plausible biological explanation of a counterintuitive phenomenon: most binding targets of a yeast transcription factor are not affected when the transcription factor is knocked out.
As shown in Figure 2, TFs with high functional redundancy show significantly lower overlap percentage (calculated using Equation (2)) than do TFs with low functional redundancy, suggesting that functional redundancy may explain why most binding targets of a TF are not affected when the TF is knocked out.
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The EU has been among the most outspoken advocates of binding targets.
These methods are all based on one assumption: most, if not all, binding targets of a TF are regulated by this TF.
Most importantly, the HLP1 binding targets from the two sets of HLP1-CLIP libraries share significant overlap (P = 0, Supplementary information, Figure S6C), suggesting the reproducibility of the CLIP experiment.
Its renewable energy law has set the world's most aggressive, legally binding target.
In this study, we show that ARF6 shares most of its binding target genes with PIF4 and they interdependently activate shared target promoters, which explains the requirement of PIFs for auxin responsive gene expression and hypocotyl elongation and the requirement of auxin for skotomorphogenesis.
Because we assume that glucose binding targets are the most extensively characterized of all compounds included in this study, these negative control screens were also used to examine the false positive rate of SMAP predictions of ligand binding.
And all governments at the most recent annual climate negotiations have agreed to set legally binding targets at the 2015 climate summit in Paris.
Most binding sites of endogenous miRNA resided in the 3′-UTR of their target mRNAs [ 21, 22].
There were no binding targets, however.
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