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There was one outliner in EF, which was caused by the slice overestimation at the most basal slice).
A smooth spatiotemporal area map was acquired for quantifying LV. Figure 5 shows two typical examples of the most apical slice estimation and the most basal slice segmentation.
Estimation of myocardial circumference might be affected by the low image contrast and signal-to-noise ratio close to the most basal slice.
The user input required by the algorithm is the definition of slices to analyze as the most basal slice and most apical slice containing any myocardium.
Of note, there were two outliers in EDV), in which one was caused by the area overestimation at the most basal slice and the another by the slice overestimation at the most apical slice; there were three outliners in ESV: one was caused by the area overestimation and two were caused by the slice overestimation at the most basal slice).
At all locations, the shapes of T2-hyperintense regions match that of infarction, not the AAR, even when there are only tiny islands of subendocardial infarction (as shown in the most basal slice).
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The most basal slices had to show at least 50% visible myocardial circumference to be included.
Segmentation of the most basal slices with outflow tract becomes more difficult when the myocardium moves in and out of the imaging plane.
Thereby, segmentation of endocardial and epicardial borders become more difficult in the most basal slices and an automatic detection of the long-axis motion is needed.
An automatic algorithm was developed for time-resolved segmentation of the endocardial and epicardial borders of the LV covering all ventricular slices from the most basal slices with outflow tract to the apex.
Including or excluding the most basal cMR slice from the measurements can indeed result in a plus or minus 10% variation in estimated volumes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com