We conclude that most basal cells express both Lrp5 and Lrp6.
However, most basal cells have a low cell surface expression of Lrp5, and only cells with a high level have enriched stem cell function.
As shown in Figures 8 and 9, a vast majority of the basal cells within undisrupted layers express both CK34βE12 and p63, while most basal cells within disrupted layers lack p63 expression with distinct signs of degeneration.
The remaining third of cancer types, which are affected by lifestyle factors, viruses or a heightened family risk, include some of the most common: Basal cell carcinoma - a type of skin cancer made more common by too much UV exposure.
Initially, the most basal epidermal cells divided and generated a subset of suprabasal cells (possibly transient-amplifying cells); within the next several days, the basal cells stopped dividing, and the suprabasal cells began proliferation, giving rise to most of the cell types in the new layers.
Moreover, the majority of cells within most basal-like cell lines showed a pL/mL and a non-CSC phenotypes (EpCAM+/CD49f+ and CD24+/CD44+), and the vast majority of luminal B and HER2-enriched cell lines also showed a pL-mL and a non-CSC phenotypes.
Conversely, most basal daughter cells divided again (17/19; Fig 2C; supplementary Movie S2 online) with a small subset (4/19) dividing ectopically in the mantle zone (supplementary Fig S4A online; supplementary Movie S3 online).
We found much lower levels of BRCA1 in most basal-like cell lines than in the non-tumourigenic HBL-100 cell line (Fig 2B).
The results showed that FOXF2 was highly expressed in most basal-like cell lines and was less expressed in non-basal-like cell lines.
