With proper education, observation and follow-up care, Dr. Bakker argues, most patients at high risk of amputation could be healed before reaching the point of no return.
Most individuals at high risk of type 2 diabetes intend to and attempt to change their lifestyle (1– 3).
Strategies with high sensitivity will correctly identify most individuals at high risk, but they will lead to unnecessary diagnostic tests and inefficient use of scarce preventive resources.
The efficacy of such measures for travelers is difficult to quantify [ 9], and most women at high risk also need chemoprophylaxis.
Our study population consisted of men over the age of 65 years and most were at high risk of a cardiovascular event.
Most children at high risk for influenza-related complications do not receive the vaccine, and increased efforts are needed to protect them.
The trials were most often at high risk of bias due to inadequate follow-up of participants, a lack of similarity at baseline across outcome measures or covariates, or inadequate blinding.
Trial and patient characteristics are described in table 2. The proportions of studies judged to be at low, unclear or high risk of bias for each domain are illustrated in figure 2. The domains most commonly at high risk of bias were outcome reporting bias (17%) and similarity across characteristics at baseline (16%).
Most children at high risk for complications do not receive the vaccine, and its use in healthy infants is not routinely accepted (8 – 10 ), even though results of recent studies suggest expanding the number of children for whom vaccination should be recommended (11 – 14 ).
If, however, the proposed hypothesis were true, the clinical implication is that while most women at high risk benefit from tamoxifen prophylaxis, there is a subset of women who would not benefit and might have ER- tumor transformation accelerated by prophylactic treatment with tamoxifen.
