"most appropriate understanding" is correct and usable in written English.
You can use it when you are describing what the most correct and accurate interpretation or way of understanding a particular situation is. For example: "Through careful thought and consideration, we have come to the most appropriate understanding of the issue at hand."
The computer program ArcGIS contains methods that are most appropriate for understanding broad spatial patterns and trends.
Qualitative research methodology is most appropriate for understanding complex constructs such as decision making [ 10].
A qualitative approach was most appropriate for understanding and describing this phenomenon of adolescent mothers' experiences of breastfeeding.
However, the crude analysis for the LUMA assay may be the most appropriate for understanding global methylation as a result of delivery type.
These course content and objectives can guide instructors to select the QL skills and concepts that are most appropriate for understanding specific biology concepts.
Unwittingly, the drivers adopted the behavior that seemed most appropriate given their understanding of the area's prevailing norms.
This new approach is certainly the most appropriate for the understanding of the physiopathology of migraine that, as a multifactorial disease, can only be assessed through the integrated study of the omics sciences.
Ferns are also the most appropriate outgroup for understanding genome structure and evolution in their sister clade, the seed plants.
There is as yet no consensus as to which format is most effective in terms of facilitating patient understanding of their risk information [ 37]; and also, what the most appropriate way to measure understanding actually is.
The important take-away -- use the shredder that is most appropriate for your needs, understanding that reconstruction is possible (you work out the probability) for the low end.
