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Thus, we were able to estimate the most appropriate prognostic markers for future clinical use.
Such changes in practice would help important evidence-based reviews to be conducted in order to establish the most appropriate prognostic markers for clinical use, which should ultimately improve patient care.
Similar(58)
Overall, our data indicate that LODS is the most appropriate clinical prognostic score for resource-constrained settings based on its simplicity to compute, non-requirement for equipment, good discrimination and calibration, and suitability for implementation in both community and health care-based settings.
Indeed, the most appropriate analysis of continuous prognostic markers may require nonlinear modelling techniques, as highlighted by Sauerbrei et al (1999); consultancy with statisticians or others experienced with such techniques is recommended in this situation.
The model based on FP-transformed covariates was most appropriate and confirmed five previously reported prognostic factors: albumin, CA19-9, alkaline phosphatase, LDH and metastases, and identified three additional factors not previously reported: WBC, AST and BUN.
Although several brain tumor markers have been studied as possible prognostic factors, further study is needed to reveal the complex mechanism of tumor genesis, thus helping to discover the most appropriate tumor markers for prognosticating the neoplasm.
There is no consensus on the most appropriate approach to handle missing covariate data within prognostic modelling studies.
Therefore, it is important to understand the prognostic factors that determine the most appropriate surgical approach in order to select patients for target-directed therapies.
However, additional studies aimed at comparing the prognostic significance of results obtained with APB and TRF assays in other tumor types are warranted to provide reliable indications on the most appropriate ALT-related marker to be used for prognostic purposes.
The challenge underlying the wealth of prognostic characterization, however, is to identify the most appropriate candidates for integration into future clinical trials.
We recommend the routine detection of gene rearrangements at ALL diagnosis in Mexican children to provide a better prognostic stratification and help to decide the most appropriate treatment, as already implemented in developed countries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com