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Despite considerable interest in the subject, there is still no consensus on the most appropriate primary therapeutic modality.
At the inaugural MDICT meeting in 2006, discussion focused on the most appropriate primary endpoints for first-in-man phase I studies of targeted anticancer agents and organisational issues of such studies.
In planning this study, there was much discussion about the most appropriate primary outcome and how this should be measured.
Power calculations for a definitive trial were performed on the different outcome measures to identify the most appropriate primary outcome measure.
Further work is also needed to establish the most appropriate primary and secondary outcomes and follow-up time in future studies of effectiveness.
It is therefore important to identify the exact extent of disease preoperatively in order to select patients for the most appropriate primary treatment.
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Although several new techniques have been introduced for CTO such as the retrograde approach, the fundamental question of what type of guidewire is the most appropriate as a primary guidewire in the antegrade approach has not been answered.
In fact, these are similar considerations we may use for selecting the most appropriate methods for primary studies.
Cases were categorised non-critical vs critical as this was considered most appropriate for a primary care setting.
Despite these alarming figures, there are no data for children aged 10 - 14 years, and very little has been invested in formulating the most appropriate strategy for primary and secondary prevention programs.
Given the evidence of early complications despite current therapeutic approaches, continuing long-term follow-up of youth with diabetes is necessary to expand our understanding of its natural history, so the most appropriate approaches to primary, secondary, and tertiary prevention of diabetes and its complications in youth can occur.
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